DJ Khaled was born in New Orleans, Louisiana. He is of Palestinian descent and lives in Pembroke Pines, Florida. Currently, he hosts the weeknight program TakeOver on Miami-based urban music radio station WEDR with fellow host K. Foxx; Khaled states that he has worked for the station professionally since 2003. In 1998, Khaled worked as a "sidekick" for Miami rapper Luther Campbell for Campbell's Friday night WEDR radio show The Luke Show. In his albums, Khaled usually provides "shoutouts" that assert his representation of "the ghetto" and urges people to listen. From 2004 to 2006, Khaled assisted in the production of the hip-hop albums Real Talk by Fabolous, True Story by Terror Squad, All or Nothing by Fat Joe, and Me, Myself, & I by Fat Joe. In June 2006, his debut album Listennn... the Album was released by Koch Records; it premiered on the Billboard 200 chart at #12.

We the Best followed in 2007 with singles "I'm So Hood" with T-Pain, Trick Daddy, Plies, and Rick Ross and "We Takin' Over" with Akon, T.I., Rick Ross, Taylor Lewis, Fat Joe, Birdman, and Lil Wayne. "We Takin' Over" peaked at #28 on the Billboard Hot 100 and #11 on the Hot Rap Tracks chart and was certified Gold by the Recording Industry Association of America on November 20, 2007.Khaled made a guest appearance on the single "100 Million" from Birdman's 2007 album 5 * Stunna; the single also featured Rick Ross, Dre, Young Jeezy and Lil Wayne. That year, Khaled won two Ozone Awards: one for Best Video ("We Takin' Over") and another for Best Radio DJ.

In 2008, Khaled's third album We Global came out with singles "Out Here Grindin" with Akon, Rick Ross, Lil' Boosie, Trick Daddy, Ace Hood, and Plies, followed by "Go Hard" featuring Kanye West and T-Pain. RIAA certified the single "I'm So Hood" Platinum on June 4, 2008. That year, Khaled won DJ of the Year awards from the BET Hip Hop Awards and Ozone Awards.

Khaled was recently appointed the president of Def Jam South.